The pH dependence of the 13C chemical shifts of the 90% enriched carboxy, and methylene carbon atoms of [CH2CO2H-13C2]carboxymethyl cobalamin shows that the carboxymethyl unit has an unusually high pK value, 7·2.
T. E. Walker, H. P. C. Hogenkamp, T. E. Needham and N. A. Matwiyoff, J. Chem. Soc., Chem. Commun., 1974, 85 DOI: 10.1039/C39740000085
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