A new synthetic method for isopavine derivatives, through one-step ring opening and ring closure of an aziridinium intermediate, and its application to a total synthesis of (±)-reframidine (3), are described.
T. Kametani, S. Hirata and K. Ogasawara, J. Chem. Soc., Perkin Trans. 1, 1973, 1466 DOI: 10.1039/P19730001466
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