The syntheses of two metabolites of flufenamic acid, 5-hydroxy-N-(ααα-trifluoro-m-tolyl)anthranilic acid and N-(4-hydroxy-ααα-trifluoro-m-tolyl)anthranilic acid, are described. Syntheses of a number of other N-aryl-anthranilic acids, mono-, di-, tri-, and tetra-substituted in the aryl ring lacking a carboxy-group, and with substituents in both aryl rings, are reported.
R. E. Bowman, K. D. Brunt, K. E. Godfrey, L. Kruszynska, A. A. Reynolds, R. I. Thrift, D. Waite and W. R. N. Williamson, J. Chem. Soc., Perkin Trans. 1, 1973, 1 DOI: 10.1039/P19730000001
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