α-Damascone has been synthesised from isoprene by acetylation, acid catalysed Diels–Alder reaction of the resulting 4-methylheza-3,5-dien-2-one with isobutylene, and final aldol condensation with acetaldehyde.
R. C. Cookson and R. M. Tuddenham, J. Chem. Soc., Chem. Commun., 1973, 742 DOI: 10.1039/C39730000742
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