Stereochemistry of the enzymic 3-hydroxylation of 1,3-dihydro-2H-1,4-benzodiazepin-2-ones
Abstract
The enzymic hydroxylation at C-3 of demethyldiazepam (1) and diazepam (2) proceeds through stereospecific removal of the pro-S hydrogen atom.
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J. Chem. Soc., Chem. Commun., 1973, 721-722
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Stereochemistry of the enzymic 3-hydroxylation of 1,3-dihydro-2H-1,4-benzodiazepin-2-ones
A. Corbella, P. Gariboldi, G. Jommi, A. Forgione, F. Marcucci, P. Martelli, E. Mussini and F. Mauri, J. Chem. Soc., Chem. Commun., 1973, 721 DOI: 10.1039/C39730000721
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