The solid-phase synthesis of some highly active aliphatic analogues of bradykinin

Abstract

The synthesis of three analogues of bradykinin is described in which the residues of L-phenylalanine in positions 5 and 8 were separately and together replaced by β-cyclohexyl-L-alanine. The synthesis, on a solid support, utilised the salt-binding principle which led to a significant increase in coupling efficiency in comparison with previous procedures. The analogues formed were of the same order of biological potency as bradykinin itself.