Carcinogenic nitrogen compounds. Part LXXX. [1]Benzopyrano-[4,3-b]indoles and 6H-[1]benzopyrano[4,3-b]quinolines

Abstract

A number of compounds derived from the [1]benzopyrano[4,3-b]indole and 6H-[1]benzopyrano[4,3-b]quinoline systems have been prepared from chroman-4-one and its 6-chloro- and 6-methyl-derivatives, and their physicochemical and biological properties investigated; analogous derivatives of the [1]benzothiopyrano[4,3-b]indole system were prepared from 6-chloro- and 6-methoxy-thiochroman-4-one. The majority of the compounds synthesised displayed high zoxazolamine hydroxylase inducing activity.