Total synthesis of nuclear analogues of 7-methyl-cephalosporin
Abstract
The synthesis of (±)-8-oxo-7β-phenylacetamido-7α-methyl-6αH-1-aza-4-thiabicyclo[4,2,0]octane-2α-carboxylic acid (5; R1= H, R2= Ph·CH2·CONH) and (±)-8-oxo-7β-phenylacetamido-7α-methyl-6αH-1-aza-4-thiabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (6; R1= H, R2= Ph·CH2) are described.