Lithiation of certain thiophen compounds has been found useful as a synthetic tool when the lithium atom can be directed to a specific ring position by the substituent; condensation of the lithiated intermediate with a variety of electrophilic reagents gave a number of specifically substituted thiophens.
D. W. Slocum and P. L. Gierer, J. Chem. Soc. D, 1971, 305 DOI: 10.1039/C29710000305
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