Analogues of folic acid having the pteridine ring replaced by quinazoline have been prepared by reductive condensation of appropriately substituted quinazoline-6-carbaldehydes and -carbonitriles with diesters of N-(p-aminobenzoyl) amino-acids, followed by hydrolysis.
J. Davoll and A. M. Johnson, J. Chem. Soc. C, 1970, 997 DOI: 10.1039/J39700000997
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