Knoevenagel condensation of 6-hydroxyindan-1-one and ethyl cyanoacetate gave the exo-unsaturated nitrile ester, which was hydrolysed and decarboxylated to 5-hydroxyindene-3-acetonitrile. 3-(2-Aminoethyl)-5-hydroxy-indene, isolated as its oxalate, was obtained by lithium aluminium hydride reduction of this nitrile.
R. M. Pinder, J. Chem. Soc. C, 1970, 114 DOI: 10.1039/J39700000114
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...