N-Monomethylation of primary aliphatic and aromatic amines can be effected rapidly, and in high yield, by treatment of the N-trifluoroacetyl derivatives with methyl iodide under basic conditions; by slight modification of the reaction conditions, N-dimethylation can be achieved. The method was suitable for N-ethylation but for N-propylation special conditions were necessary to obtain satisfactory yields.
R. A. W. Johnstone, D. W. Payling and C. Thomas, J. Chem. Soc. C, 1969, 2223 DOI: 10.1039/J39690002223
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