The Friedel-Crafts acylation of aromatic halogen derivatives. Part III. The benzoylation of chlorobenzene

Abstract

The Friedel-Crafts benzoylation of chlorobenzene leads to mixtures of o-(3–12%), m-(0.1–4%), and p-(84–97%) chlorobenzophenones and benzophenone (0–8%). The effects of solvent, catalyst, mode of addition, temperature, and duration of the reaction have been examined. The reactivity ratio of chlorobenzene: benzene has been found to be 0.0260 in nitrobenzene solution at 25°, leading to the partial rate factors o_f= 0.00328, m_f= 0.00016, and p_f= 0.150.