The absolute configurations of some aryl- and alkyl-substituted 3-phenylpropanoic acids

Abstract

The configuration of (+)-2,3-diphenylpropanoic acid has been related to that of (R)-(–)-2-phenylpropanoic acid by converting both acids into (+)-1,2-diphenylpropane. The configuration of (+)-2-methyl-3-phenylpropanoic acid has been related to that of (R)-(+)-3-phenyl-2-(2-thienyl)propanoic acid by converting both acids into (+)-2-methyl-1-phenylhexane. (R)-(+)-3-Phenyl-2-(2-thienyl)propanoic acid has also been reduced to (–)-2-benzylhexanoic acid thus establishing the configuration of the latter.