Pyrimidines. Part XV. The nitrosation of 4,6-dimethyl- and 4-methyl-6-phenyl-pyrimidin-2-ols

Abstract

The nitrosation of the title compounds has been shown to give 4-hydroxyiminomethyl-6-methyl- and 4-hydroxyiminomethyl-6-phenyl-pyrimidin-2-ol, respectively. When the two latter compounds are treated with phosphoryl chloride the hydroxy groups are replaced by chlorine and the hydroxyiminomethyl groups are dehydrated to give cyano groups. The preparation of 4-hydrazino-6-phenylpyrimidine-2-carbonitrile and an improved synthesis of 4-methyl-6-phenylpyrimidin-2-ol are also recorded.