The chemical biology of coronavirus host–cell interactions
Chemical biology strategies can play important roles in studying the complexity of SARS-CoV-2–host interactions at molecular level detail.
Transfer hydrogenation catalysis in cells
Recent developments in transfer hydrogenation catalysis and photocatalysis in cancer cells by synthetic metal complexes are reviewed. They offer exciting new ways to modulate biochemical pathways for drug development and biotechnology.
DNA folds threaten genetic stability and can be leveraged for chemotherapy
Alternative DNA structures (including G-quadruplexes and DNA junctions) represent promising targets for combinatorial chemotherapeutic treatments aiming at fostering genomic instability and impeding DNA repair.
Structural motifs and intramolecular interactions in non-canonical G-quadruplexes
G-rich nucleic acid sequences encompassing G-tracts of varying lengths can fold into different non-canonical G-quadruplexes with distinct structural features.
Matters of class: coming of age of class III and IV lanthipeptides
In this review, we give a concise overview of the known biosynthetic princples of class III and IV lanthipeptide synthtases.
Tools for functional dissection of site-specific O-GlcNAcylation
An overview of the latest tools and technologies to investigate the roles of site-specific O-GlcNAcylation in vitro and in vivo.
In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery
Using the protein–protein interaction of Mcl-1/Noxa, two methods for efficient modulator discovery are directly compared.
A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions
We show for the first time that PD-1 is palmitoylated, identify DHHC9 as the predominant enzyme for its palmitoylation, and reveal the molecular mechanisms underlying its effects on PD-1 stability and functions. Importantly, we also designed PD1-PALM, a competitive inhibitor of PD-1 palmitoylation, and this first-in-class molecule may inspire the development of new checkpoint inhibitors.
Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications
Using protein semi-synthesis, segmentally isotope-labelled variants of nucleosome-binding protein HMGN1 were generated with site-specific posttranslational modifications to explore their structural and functional effects.
In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides
Cyclic peptides containing unnatural amino acids can modulate Lys-48 ubiquitin chains in cells and animals.
Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors
We identified potent, functionalisable BMX inhibitors and revealed their covalent mode of binding to BMX by X-ray crystallography.
Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding
Altering local dielectric properties induced by solvent shielding, enhances polar interactions and leads to enthalpically driven recognition of polar substrates.
Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint
Leveraging interface peptides in PD-L1 for PET imaging of PD-1, providing a new paradigm for radiotracer development.
Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents
Naphthalimide-appended oligopyridylamide peptidomimetic modulate islet amyloid polypeptide amyloidogenesis and disaggregate preformed oligomers and fibrils into non-toxic conformations at substoichiometric concentration.
A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families
In-depth study of intriguing bacterial interrupted adenylation domains from seven distinct families and six different types.
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