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Themed collection RSC Chemical Biology Editors' Choice

15 items
Open Access Review Article

The chemical biology of coronavirus host–cell interactions

Chemical biology strategies can play important roles in studying the complexity of SARS-CoV-2–host interactions at molecular level detail.

Graphical abstract: The chemical biology of coronavirus host–cell interactions
Open Access Review Article

Transfer hydrogenation catalysis in cells

Recent developments in transfer hydrogenation catalysis and photocatalysis in cancer cells by synthetic metal complexes are reviewed. They offer exciting new ways to modulate biochemical pathways for drug development and biotechnology.

Graphical abstract: Transfer hydrogenation catalysis in cells
From the themed collection: RSC Chemical Biology Editors' Choice
Open Access Review Article

DNA folds threaten genetic stability and can be leveraged for chemotherapy

Alternative DNA structures (including G-quadruplexes and DNA junctions) represent promising targets for combinatorial chemotherapeutic treatments aiming at fostering genomic instability and impeding DNA repair.

Graphical abstract: DNA folds threaten genetic stability and can be leveraged for chemotherapy
Open Access Review Article

Structural motifs and intramolecular interactions in non-canonical G-quadruplexes

G-rich nucleic acid sequences encompassing G-tracts of varying lengths can fold into different non-canonical G-quadruplexes with distinct structural features.

Graphical abstract: Structural motifs and intramolecular interactions in non-canonical G-quadruplexes
From the themed collection: RSC Chemical Biology Editors' Choice
Open Access Review Article

Matters of class: coming of age of class III and IV lanthipeptides

In this review, we give a concise overview of the known biosynthetic princples of class III and IV lanthipeptide synthtases.

Graphical abstract: Matters of class: coming of age of class III and IV lanthipeptides
Open Access Review Article

Tools for functional dissection of site-specific O-GlcNAcylation

An overview of the latest tools and technologies to investigate the roles of site-specific O-GlcNAcylation in vitro and in vivo.

Graphical abstract: Tools for functional dissection of site-specific O-GlcNAcylation
From the themed collection: RSC Chemical Biology Editors' Choice
Open Access Paper

In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery

Using the protein–protein interaction of Mcl-1/Noxa, two methods for efficient modulator discovery are directly compared.

Graphical abstract: In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery
Open Access Paper

A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions

We show for the first time that PD-1 is palmitoylated, identify DHHC9 as the predominant enzyme for its palmitoylation, and reveal the molecular mechanisms underlying its effects on PD-1 stability and functions. Importantly, we also designed PD1-PALM, a competitive inhibitor of PD-1 palmitoylation, and this first-in-class molecule may inspire the development of new checkpoint inhibitors.

Graphical abstract: A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions
From the themed collection: RSC Chemical Biology Editors' Choice
Open Access Paper

Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications

Using protein semi-synthesis, segmentally isotope-labelled variants of nucleosome-binding protein HMGN1 were generated with site-specific posttranslational modifications to explore their structural and functional effects.

Graphical abstract: Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications
Open Access Paper

In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides

Cyclic peptides containing unnatural amino acids can modulate Lys-48 ubiquitin chains in cells and animals.

Graphical abstract: In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides
Open Access Paper

Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors

We identified potent, functionalisable BMX inhibitors and revealed their covalent mode of binding to BMX by X-ray crystallography.

Graphical abstract: Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors
Open Access Paper

Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding

Altering local dielectric properties induced by solvent shielding, enhances polar interactions and leads to enthalpically driven recognition of polar substrates.

Graphical abstract: Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding
From the themed collection: RSC Chemical Biology Editors' Choice
Open Access Paper

Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint

Leveraging interface peptides in PD-L1 for PET imaging of PD-1, providing a new paradigm for radiotracer development.

Graphical abstract: Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint
From the themed collection: RSC Chemical Biology Editors' Choice
Open Access Paper

Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents

Naphthalimide-appended oligopyridylamide peptidomimetic modulate islet amyloid polypeptide amyloidogenesis and disaggregate preformed oligomers and fibrils into non-toxic conformations at substoichiometric concentration.

Graphical abstract: Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents
From the themed collection: RSC Chemical Biology Editors' Choice
Open Access Paper

A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families

In-depth study of intriguing bacterial interrupted adenylation domains from seven distinct families and six different types.

Graphical abstract: A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families
15 items

About this collection

This collection celebrates the very best work published in RSC Chemical Biology, including articles personally chosen by our world-renowned editorial team, and articles highlighted as “HOT”.  New selections will be added on a monthly basis.

You can read the thoughts of our Editorial Board on each of their selected articles here.

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