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Effect of end group polarity upon the lower critical solution temperature of poly(2-isopropyl-2-oxazoline)

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Abstract

Thermo-sensitive poly(2-isopropyl-2-oxazoline)s (PiPrOx) were functionalized with end groups of different polarity by living cationic ring-opening polymerization using the initiator and/or termination method as well as sequential block copolymerization with 2-methyl-2-oxazoline. As end groups, methyl, n-nonyl, piperidine, piperazine as well as oligo(ethylenglygol) and oligo(2-methyl-2-oxazoline) were introduced quantitatively. The lower critical solution temperature (LCST) of the aqueous solutions was investigated. The introduction of hydrophobic end groups decreases the LCST, while hydrophilic polymer tails raise the cloud point. In comparison to poly(N-isopropyl acrylamide), the impact of the end group polarity upon the modulation of the LCST was found to be significantly stronger. Surprisingly, terminal oligoethylenegycol units also decrease the LCST of PiPrOx, thus acting as moieties of higher hydrophobicity as compared to the poly(2-oxazoline) main chain. Together with the possible variation of the side group polarity, this allows a broad modulation of the LCST of poly(2-oxazoline)s.

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Acknowledgements

This work was financially supported by the Deutsche Forschungsgemeinschaft (DFG) through the project JO287/4-3.

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Authors and Affiliations

  1. Wacker-Lehrstuhl für Makromolekulare Chemie, Department Chemie, Technische Universität München, Lichtenbergstr.4, 85747, Garching, Germany

    Stephan Huber, Naima Hutter & Rainer Jordan

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  1. Stephan Huber
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  2. Naima Hutter
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  3. Rainer Jordan
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Correspondence to Rainer Jordan.

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Huber, S., Hutter, N. & Jordan, R. Effect of end group polarity upon the lower critical solution temperature of poly(2-isopropyl-2-oxazoline). Colloid Polym Sci 286, 1653–1661 (2008). https://doi.org/10.1007/s00396-008-1942-7

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  • DOI: https://doi.org/10.1007/s00396-008-1942-7

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