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Chapter 6

Enzyme-Responsive Hydrogels for Biomedical Applications

This chapter highlights recent developments in enzyme-responsive gels. The focus is on peptide-based small-molecule hydrogels, for biomedical applications. The use of enzymes in this context provides a powerful methodology for controlled assembly, taking advantage of both biological selectivity and catalytic amplification. The building blocks for self-assembly and basic design rules for small molecule peptide gelators are discussed first. This is followed by a discussion of key features of biocatalytic self-assembly of hydrogels, focusing on control of nanoscale organization and consequent function. Finally, the potential applications of the enzyme-responsive hydrogels as biomaterials are discussed in the areas of cell culture, drug delivery, biosensing, and control of cell fate.

Print publication date: 18 Mar 2014
Copyright year: 2014
Print ISBN: 978-1-84973-798-2
PDF eISBN: 978-1-78262-205-5
ePub eISBN: 978-1-78262-126-3
From the book series:
Soft Matter Series