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Issue 6, 2018
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Phototoxicity of traditional chinese medicine (TCM)

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Abstract

Phototoxicity can cause toxic responses such as edemas and lesions, and is one of the severe adverse effects that largely limit the use of these phototoxic drugs. Some traditional Chinese medicines (TCMs) and their constituents have been reported to be phototoxic. However, to date, their phototoxicity information is still very limited, and lacks systemic investigation. This article presents the phototoxicity potential of various types of TCMs and their active components in an effort to provide valuable information for drug research and discovery to mitigate phototoxicity concerns. Some potential mechanisms of action (MoAs) of phototoxicity are discussed. In addition, in vivo and in vitro phototoxicity assays are summarized this review.

Graphical abstract: Phototoxicity of traditional chinese medicine (TCM)

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Publication details

The article was received on 25 May 2018, accepted on 25 Aug 2018 and first published on 27 Aug 2018


Article type: Review Article
DOI: 10.1039/C8TX00141C
Toxicol. Res., 2018,7, 1012-1019

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    Phototoxicity of traditional chinese medicine (TCM)

    X. Li, R. An, K. Liang, X. Wang and L. You, Toxicol. Res., 2018, 7, 1012
    DOI: 10.1039/C8TX00141C

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