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Issue 5, 2018
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Bioactive nano-metal–organic frameworks as antimicrobials against Gram-positive and Gram-negative bacteria

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Abstract

More effective antibiotics are needed to overcome the problem of multidrug resistance. The antibacterial efficacies of three Zn-based nano metal–organic frameworks (nMOFs) – IRMOF-3, MOF-5, and Zn-BTC – were explored, both alone and as mixtures with ampicillin and kanamycin. When tested against Escherichia coli, Staphylococcus aureus, Staphylococcus lentus, and Listeria monocytogenes, the nMOF/drug mixtures demonstrated synergistic (IRMOF-3/kanamycin) or additive (other nMOF/drug combinations) effects compared with the nMOFs or antibiotics alone. Zn-Based nMOFs can reduce the burden of the new discovery of antimicrobial pharmaceuticals by increasing the potency of existing antibiotics.

Graphical abstract: Bioactive nano-metal–organic frameworks as antimicrobials against Gram-positive and Gram-negative bacteria

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Supplementary files

Article information


Submitted
23 Mar 2018
Accepted
10 May 2018
First published
11 May 2018

Toxicol. Res., 2018,7, 931-941
Article type
Paper

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