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Issue 6, 2015

The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells

Author affiliations

Abstract

The anticancer activity of disulfiram (DS) is copper(II) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity introduced by the end product, DDC-Cu. Nanoencapsulation of DS might shed light on repositioning of DS into cancer treatment.

Graphical abstract: The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells

Article information


Submitted
27 Jun 2015
Accepted
30 Aug 2015
First published
01 Sep 2015

This article is Open Access

Toxicol. Res., 2015,4, 1439-1442
Article type
Communication

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