A robust CRISPR–Cas12a biosensor coated with metal–organic framework

Lingjun Sha; Yiwei Han; Minghui Wang; Shuai Wu; Jie Yang; Genxi Li

doi:10.1039/D1TB01126J

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A robust CRISPR–Cas12a biosensor coated with metal–organic framework†

Lingjun Sha,^a Yiwei Han,^b Minghui Wang,^b Shuai Wu,*^b Jie Yang^b and Genxi Li

*^ab

Author affiliations

* Corresponding authors

^a Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China
E-mail: genxili@nju.edu.cn

^b State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China
E-mail: shwu@njmu.edu.cn

Abstract

Metal–organic frameworks (MOFs) are proposed to protect a CRISPR-associated enzyme/RNA complex from harsh environments, while the complex can be quickly released from MOFs with high efficiency. Therefore, the application of CRISPR-powered biosensing can be more feasible.

This article is part of the themed collection: Journal of Materials Chemistry B HOT Papers

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Article information

DOI: https://doi.org/10.1039/D1TB01126J
Article type: Communication
Submitted: 19 May 2021
Accepted: 20 Jun 2021
First published: 21 Jun 2021

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J. Mater. Chem. B, 2021,9, 5451-5455

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A robust CRISPR–Cas12a biosensor coated with metal–organic framework

L. Sha, Y. Han, M. Wang, S. Wu, J. Yang and G. Li, J. Mater. Chem. B, 2021, 9, 5451 DOI: 10.1039/D1TB01126J

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Journal of Materials Chemistry B

A robust CRISPR–Cas12a biosensor coated with metal–organic framework†

Abstract

Supplementary files

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A robust CRISPR–Cas12a biosensor coated with metal–organic framework

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