Issue 10, 2021

Chem-inspired hollow ceria nanozymes with lysosome-targeting for tumor synergistic phototherapy

Abstract

The precise operation of the hypoxic tumor microenvironment presents a promising way to improve treatment efficacy, in particular in tumor synergistic phototherapy. This work reports an innovative approach to build adenosine triphosphate-modified hollow ceria nanozymes (ATP-HCNPs@Ce6) that manipulate tumor hypoxia to effectively achieve drug delivery. Hollow ceria nanoparticles (HCNPs) exhibit a controllable hollow structure through varying nitric acid concentrations in the nanocomposites. Specifically, ATP modification makes HCNPs exceptionally biocompatible and stable and acts as a regulator of HCNP enzymatic activity. In the stage of drug loading, newly prepared ATP-HCNPs@Ce6 serves as an in situ oxygen-generating agent because of its ability to simulate catalase. Therefore, ATP-HCNPs@Ce6 has adjustable enzymatic properties that act like a “switch” to selectively supply oxygen in response to high levels of hydrogen peroxide expression and the slightly acidic lysosomal environment of the tumor to enhance lysosome-targeted photodynamic therapy. Moreover, the obvious anticancer effects of ATP-HCNPs@Ce6 are demonstrated in vitro and in vivo. Overall, a simple and rapid self-assembly strategy to form and modify multifunctional HCNPs is reported, which may further propel their application in the field of precision tumor treatment.

Graphical abstract: Chem-inspired hollow ceria nanozymes with lysosome-targeting for tumor synergistic phototherapy

Supplementary files

Article information

Article type
Paper
Submitted
07 Dec 2020
Accepted
06 Feb 2021
First published
06 Feb 2021

J. Mater. Chem. B, 2021,9, 2515-2523

Chem-inspired hollow ceria nanozymes with lysosome-targeting for tumor synergistic phototherapy

L. Zhou, W. Li, Y. Wen, X. Fu, F. Leng, J. Yang, L. Chen, X. Yu, C. Yu and Z. Yang, J. Mater. Chem. B, 2021, 9, 2515 DOI: 10.1039/D0TB02837A

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