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Issue 31, 2020
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Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

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Abstract

Tumor-derived extracellular vesicles have emerged as an alternative source of cancer biomarkers in liquid biopsies. Despite their clinical potential, traditional methods for isolation and analysis have hampered their translation into the clinic. The use of nanomaterial-based biosensors can speed up the development of analytical methods for quantifying extracellular vesicles in a specific, highly reproducible, robust, fast and inexpensive way. Here we review the utility of extracellular vesicles as a novel type of liquid biopsies and the recent advances in nanoparticle-based biosensors for their analysis. We aim to emphasise the limitations and challenges that hinder extracellular vesicle analysis using these biosensors and point out potential solutions.

Graphical abstract: Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

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Article information


Submitted
01 Apr 2020
Accepted
02 Jun 2020
First published
04 Jun 2020

This article is Open Access

J. Mater. Chem. B, 2020,8, 6710-6738
Article type
Review Article

Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

B. Martín-Gracia, A. Martín-Barreiro, C. Cuestas-Ayllón, V. Grazú, A. Line, A. Llorente, J. M. de la Fuente and M. Moros, J. Mater. Chem. B, 2020, 8, 6710 DOI: 10.1039/D0TB00861C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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