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Issue 18, 2020
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A novel elastic and controlled-release poly(ether-ester-urethane)urea scaffold for cartilage regeneration

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Abstract

In the tissue engineering of cartilage, scaffolds with appropriate elasticity and controlled-release properties are essential. Herein, we synthesized a poly(ether-ester-urethane)urea scaffold with a pendant amino group (PEEUUN) through a de-protection process from PEEUU-Boc polymers and grafted kartogenin (KGN) onto the PEEUUN scaffolds (PEEUUN-KGN). Characterization, performance tests, scaffold biocompatibility analysis, and chondrogenesis evaluation both in vitro and in vivo were conducted. The results revealed that the PEEUUN-KGN scaffolds were degradable and three-dimensional (3D) with interconnected pores, and possessed good elasticity, as well as excellent cytocompatibility. Meanwhile, KGN on the PEEUUN-KGN scaffolds underwent stable sustained release for a long time and promoted human umbilical cord mesenchymal stem cells (HUCMSCs) to differentiate into chondrocytes in vitro, thus enhancing cartilage regeneration in vivo. In conclusion, the present PEEUUN-KGN scaffolds would have application potential for cartilage tissue engineering.

Graphical abstract: A novel elastic and controlled-release poly(ether-ester-urethane)urea scaffold for cartilage regeneration

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Article information


Submitted
04 Dec 2019
Accepted
20 Mar 2020
First published
20 Mar 2020

J. Mater. Chem. B, 2020,8, 4106-4121
Article type
Paper

A novel elastic and controlled-release poly(ether-ester-urethane)urea scaffold for cartilage regeneration

C. Chen, K. Huang, J. Zhu, Y. Bi, L. Wang, J. Jiang, T. Zhu, X. Yan and J. Zhao, J. Mater. Chem. B, 2020, 8, 4106
DOI: 10.1039/C9TB02754H

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