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Issue 3, 2020
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Photodynamic antitumor activity of Ru(ii) complexes of imidazo-phenanthroline conjugated hydroxybenzoic acid as tumor targeting photosensitizers

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Abstract

Two novel Ru(II) polypyridyl complexes bearing imidazo-phenanthroline conjugated hydroxybenzoic acid groups were designed to enhance the tumor targeting ability as photosensitizers for photodynamic therapy. [Ru(bpy)2(phcpip)] (ClO4)2 (Ru-1) and [Ru(bpy)2(ohcpip)] (ClO4)2 (Ru-2) (bpy = 2,2′-bipyridine; phcpip = 2-(3-carboxyl-4-hydroxyphenyl) imidazo [4,5-f]phenanthroline; ohcpip = 2-(2-hydroxyl-3-carboxyphenyl) imidazo [4,5-f] [1,10] phenanthroline) were synthesized and their photodynamic antitumor activities were investigated. Both complexes displayed high photocytotoxicity toward cancerous cell lines HepG2, A549, MCF-7, and MDA-MB-231, but low photocytotoxicity toward normal cell lines GES-1 and Huvec. They were mainly localized at the nucleus of HepG2 cells after 24 h incubation, arrested the cell cycle at the G2/M phase and induced cancer cell apoptosis through reactive oxygen species (ROS) mediated pathways. Tumor targeting of the complexes is attributed to stronger molecular binding to DNA.

Graphical abstract: Photodynamic antitumor activity of Ru(ii) complexes of imidazo-phenanthroline conjugated hydroxybenzoic acid as tumor targeting photosensitizers

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Supplementary files

Article information


Submitted
26 Sep 2019
Accepted
29 Nov 2019
First published
02 Dec 2019

J. Mater. Chem. B, 2020,8, 438-446
Article type
Paper

Photodynamic antitumor activity of Ru(II) complexes of imidazo-phenanthroline conjugated hydroxybenzoic acid as tumor targeting photosensitizers

Z. Liu, J. Zhang, Y. Sun, C. Zhu, Y. Lu, J. Wu, J. Li, H. Liu and Y. Ye, J. Mater. Chem. B, 2020, 8, 438
DOI: 10.1039/C9TB02103E

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