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Issue 32, 2019
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Diselenium-containing ultrathin polymer nanocapsules for highly efficient targeted drug delivery and combined anticancer effect

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Abstract

The combination of selenium and pillararenes to prepare selenium-containing pillararene-based biomaterials is of great significance for the development of biomedicine. Herein, using a covalent self-assembly strategy, we successfully developed new diselenium-containing ultrathin polymer nanocapsules based on lateral cross-linked pillararenes. The new system exhibited a very potent anticancer effect; additionally, the incorporation of the cleavable redox diselenium bond into the polymer nanocapsules provided a smart nanocarrier for drug delivery. Moreover, the polymer nanocapsules were developed for anticancer drug targeting delivery by loading an anticancer drug and introducing the tumor-penetrating peptide RGD through the host–guest interaction strategy. The targeting DOX-loaded diselenium-containing polymer nanocapsules exhibited enhanced stability, self-anticancer effect, targeted delivery and controlled drug release, resulting in effective combined inhibition of tumor progression.

Graphical abstract: Diselenium-containing ultrathin polymer nanocapsules for highly efficient targeted drug delivery and combined anticancer effect

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Article information


Submitted
16 Jun 2019
Accepted
02 Jul 2019
First published
03 Jul 2019

J. Mater. Chem. B, 2019,7, 4927-4932
Article type
Communication

Diselenium-containing ultrathin polymer nanocapsules for highly efficient targeted drug delivery and combined anticancer effect

S. Fu, F. Li, M. Zang, Z. Zhang, Y. Ji, X. Yu, Q. Luo, S. Guan, J. Xu and J. Liu, J. Mater. Chem. B, 2019, 7, 4927
DOI: 10.1039/C9TB01200A

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