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Issue 30, 2019
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Engineering FeCo alloy@N-doped carbon layers by directly pyrolyzing Prussian blue analogue: new peroxidase mimetic for chemiluminescence glucose biosensing

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Abstract

Herein, we report the synthesis of FeCo alloy@N-doped carbon layers (FeCo@NC), a new peroxidase mimetic, by directly pyrolyzing the FeIII–Co Prussian blue analogue (FeIII–Co PBA). The FeCo@NC composite showed excellent peroxidase-like activity due to its highly active FeCo alloy, M–N species (Co–N and Fe–N) and N-doped carbon layers with hierarchical pore nanostructures, which were formed via simple heat treatment of FeIII–Co PBA without additional C and N sources. In particular, the obtained FeCo@NC hybrid presented high CL activity with more than 85-fold enhancement in the CL emission of the H2O2–luminol system, and long-term stability compared with FeCo alloy nanoparticles. The CL response showed a linear range of 0.01–40 μM H2O2 with a limit of detection of 2.5 nM. When coupled with glucose oxidase, we developed a new CL sensing method for the detection of glucose in the linear range of 10 nM to 10 μM with a detection limit of 8.5 nM. This FeCo@NC-based glucose biosensor displayed rapidity, high precision and good reproducibility when utilized to analyze real biological samples. Expectedly, FeCo@NC, as a new peroxidase mimetic, exhibits great potential for monitoring glucose levels in clinical diagnosis.

Graphical abstract: Engineering FeCo alloy@N-doped carbon layers by directly pyrolyzing Prussian blue analogue: new peroxidase mimetic for chemiluminescence glucose biosensing

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Supplementary files

Article information


Submitted
24 Apr 2019
Accepted
23 Jun 2019
First published
25 Jun 2019

J. Mater. Chem. B, 2019,7, 4661-4668
Article type
Paper

Engineering FeCo alloy@N-doped carbon layers by directly pyrolyzing Prussian blue analogue: new peroxidase mimetic for chemiluminescence glucose biosensing

Y. Lu, X. Zhang, X. Mao and Y. Huang, J. Mater. Chem. B, 2019, 7, 4661
DOI: 10.1039/C9TB00797K

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