Issue 28, 2019

Biocompatible and multifunctional gold nanorods for effective photothermal therapy of oral squamous cell carcinoma

Abstract

Herein, a cysteine-functionalized alginate was used to replace cytotoxic cetyltrimethylammonium bromide (CTAB) on gold nanorods (GNRs) by gold–thiol bonding. The characterization shows that the alginate-modified GNRs (GNR@Alg-Cys) were 137 nm in length (measured by zetasizer) with a negative surface charge (−28.4 mV). The GNR@Alg-Cys showed an intense absorption at 800 nm, indicating the potential of GNR@Alg-Cys for NIR-excited photothermal therapy (PTT). To target cancer cells, a cyclic peptide, c(RGDfK)KKK, was further modified on GNR@Alg-Cys (denoted as GNR@Alg-Cys/RGD). In vitro experiments reveal the apparently enhanced cell viability under a high dose of GNRs as well as the death of SAS-3 cell lines exposed to a single-wavelength laser (808 nm). The animal study revealed that the volume of GNR@Alg-Cys/RGD-treated laser-exposed tumor was reduced five times when compared with that in the case of the control group (PBS-treated tumor). Furthermore, the in vivo toxicity of GNR@Alg-Cys/RGD was evaluated, and no significant effect was observed on the functions of liver and kidneys after PTT.

Graphical abstract: Biocompatible and multifunctional gold nanorods for effective photothermal therapy of oral squamous cell carcinoma

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
24 Mar 2019
Accepted
11 Jun 2019
First published
13 Jun 2019

J. Mater. Chem. B, 2019,7, 4451-4460

Biocompatible and multifunctional gold nanorods for effective photothermal therapy of oral squamous cell carcinoma

Y. Liao, C. Liu, Y. Chin, S. Chen, S. H. Liu, Y. Hsu and K. C.-W. Wu, J. Mater. Chem. B, 2019, 7, 4451 DOI: 10.1039/C9TB00574A

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