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Issue 23, 2019
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Dual-channel fluorescent probe bearing two-photon activity for cell viability monitoring

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Abstract

The search for a highly sensitive and efficient method to monitor cell viability is a high-priority yet challenging. In this study, two chromophores, 1OC and 2OC, were rationally designed and fabricated to achieve excellent biocompatibility and two-photon activity in the near-infrared region. Fortunately, because of the introduction of water-soluble moieties and biocompatible triazole groups that link with the ether oxygen chain via a “Click” reaction, the obtained 2OC displayed considerable biocompatibility and two-photon activity. Moreover, it revealed dual-channel fluorescence microscopy imaging for nucleolar and mitochondrial targeting, which can be employed for cell viability monitoring.

Graphical abstract: Dual-channel fluorescent probe bearing two-photon activity for cell viability monitoring

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Supplementary files

Article information


Submitted
14 Mar 2019
Accepted
13 May 2019
First published
14 May 2019

J. Mater. Chem. B, 2019,7, 3633-3638
Article type
Communication

Dual-channel fluorescent probe bearing two-photon activity for cell viability monitoring

Y. Zhao, C. Zhang, J. Liu, D. Li, X. Tian, A. Wang, S. Li, J. Wu and Y. Tian, J. Mater. Chem. B, 2019, 7, 3633
DOI: 10.1039/C9TB00512A

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