A multifunctional low-generation dendrimer-based nanoprobe for the targeted dual mode MR/CT imaging of orthotopic brain gliomas

Xiaoying Xu; Kang Liu; Yue Wang; Changchang Zhang; Menghan Shi; Peng Wang; Linghong Shen; Jindong Xia; Ling Ye; Xiangyang Shi; Mingwu Shen

doi:10.1039/C9TB00416E

A multifunctional low-generation dendrimer-based nanoprobe for the targeted dual mode MR/CT imaging of orthotopic brain gliomas†

Xiaoying Xu,‡^a Kang Liu,‡^be Yue Wang,

‡^c Changchang Zhang,^a Menghan Shi,^a Peng Wang,^a Linghong Shen,^d Jindong Xia,*^c Ling Ye,

*^b Xiangyang Shi

*^a and Mingwu Shen

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-dimension Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China
E-mail: mwshen@dhu.edu.cn, xshi@dhu.edu.cn

^b School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, People's Republic of China
E-mail: lingye@ccmu.edu.cn

^c Department of Radiology, Shanghai Songjiang District Central Hospital, Shanghai 201600, People's Republic of China
E-mail: xiajd_21@163.com

^d Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200030, People's Republic of China

^e Department of Pharmacy, Electric Power Teaching Hospital, Capital Medical University, Beijing 100073, People's Republic of China

Abstract

An RGD peptide-targeted low-generation dendrimer-based nanoprobe has been developed through the versatile dendrimer nanotechnology. The poly(amidoamine) dendrimers of generation 2 can be modified or loaded with Mn chelates, RGD peptide, and gold nanoparticles to have desired stability, cytocompatibility, cancer cell targeting specificity, and ability to cross the blood-brain barrier for targeted MR/CT imaging of an orthotopic brain glioma.

Journal of Materials Chemistry B

A multifunctional low-generation dendrimer-based nanoprobe for the targeted dual mode MR/CT imaging of orthotopic brain gliomas†

Abstract

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A multifunctional low-generation dendrimer-based nanoprobe for the targeted dual mode MR/CT imaging of orthotopic brain gliomas

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