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Issue 21, 2019
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Development of a two-photon fluorescent probe for the selective detection of β-galactosidase in living cells and tissues

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Abstract

The development of two-photon bio-imaging probes for trapping specific enzyme activities in overexpressed tissue is very practical and significant. In this work, we developed a two-photon fluorescent β-gal probe G-GAL, which was made with GCTPOC as the fluorescence reporter and a β-galactosidase cleavable crew as the enzyme activity initiator. The purpose of designing this probe was to detect β-galactosidase in living cells and tissues. The probe G-GAL has the advantage of rapid response, great fluorescence enhancement and superior specificity. Furthermore, the probe has excellent tissue penetration.

Graphical abstract: Development of a two-photon fluorescent probe for the selective detection of β-galactosidase in living cells and tissues

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Supplementary files

Article information


Submitted
25 Jan 2019
Accepted
15 Apr 2019
First published
16 Apr 2019

J. Mater. Chem. B, 2019,7, 3431-3437
Article type
Paper

Development of a two-photon fluorescent probe for the selective detection of β-galactosidase in living cells and tissues

Z. Li, M. Ren, L. Wang, L. Dai and W. Lin, J. Mater. Chem. B, 2019, 7, 3431
DOI: 10.1039/C9TB00175A

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