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Issue 15, 2019
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An AIE-active theranostic probe for light-up detection of Aβ aggregates and protection of neuronal cells

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Abstract

Alzheimer's disease (AD) is one of the most serious health threats in our aging society. The major pathological feature of AD is excessive extracellular aggregation of β-amyloid (Aβ) protein in the form of Aβ fibrils or plaques. The simultaneous detection of Aβ fibrils and inhibition of their neurotoxicity is highly desirable for study of Alzheimer's disease. Although various fluorophores have been developed for imaging of Aβ fibrils or plaques, they suffer from serious self-quenching at high concentration and a lack of neuroprotective functions. To tackle these challenges, we herein develop a multi-functional probe of Cur-N-BF2 with aggregation-induced emission (AIE) characteristics for light-up detection of Aβ fibrils and plaques, inhibition of Aβ fibrillation, disassembly of preformed Aβ fibrils, and protection of neuronal cells. The AIE-active theranostic probe is thus promising for study of Aβ fibrils and plaques in Alzheimer's disease.

Graphical abstract: An AIE-active theranostic probe for light-up detection of Aβ aggregates and protection of neuronal cells

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Supplementary files

Article information


Submitted
19 Jan 2019
Accepted
01 Mar 2019
First published
04 Mar 2019

J. Mater. Chem. B, 2019,7, 2434-2441
Article type
Paper

An AIE-active theranostic probe for light-up detection of Aβ aggregates and protection of neuronal cells

Y. Yang, S. Li, Q. Zhang, Y. Kuang, A. Qin, M. Gao, F. Li and B. Z. Tang, J. Mater. Chem. B, 2019, 7, 2434
DOI: 10.1039/C9TB00121B

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