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Issue 28, 2019
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Outsmarting superbugs: bactericidal activity of nanostructured titanium surfaces against methicillin- and gentamicin-resistant Staphylococcus aureus ATCC 33592

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Abstract

The colonisation of biomaterial surfaces by pathogenic bacteria is a significant issue of concern, particularly in light of the rapid rise of antibiotic resistance. Current strategies are proving ineffective as multi-drug resistant pathogenic bacteria emerge. Recently, it was discovered that surfaces with nanoscale features are capable of physically rupturing bacteria and hence displaying mechano-bactericidal activity. In this study, we investigated the interactions between methicillin- and gentamicin-susceptible and -resistant Staphylococcus aureus strains and nanostructured titanium surfaces, fabricated using a hydrothermal etching process. The nanostructured titanium surfaces proved to be equally effective and highly bactericidal against both the susceptible and resistant S. aureus strains, with killing efficiencies of 80.7% ± 12.0 and 86.8% ± 11.6, respectively. The mechano-bactericidal activity of these nanostructured titanium surfaces offers an innovative solution to establish medical device surfaces with antimicrobial activity in the context of increasing antibiotic resistance.

Graphical abstract: Outsmarting superbugs: bactericidal activity of nanostructured titanium surfaces against methicillin- and gentamicin-resistant Staphylococcus aureus ATCC 33592

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Publication details

The article was received on 17 Jan 2019, accepted on 07 Jun 2019 and first published on 11 Jun 2019


Article type: Paper
DOI: 10.1039/C9TB00102F
J. Mater. Chem. B, 2019,7, 4424-4431

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    Outsmarting superbugs: bactericidal activity of nanostructured titanium surfaces against methicillin- and gentamicin-resistant Staphylococcus aureus ATCC 33592

    J. V. Wandiyanto, S. Cheeseman, V. K. Truong, M. A. Kobaisi, C. Bizet, S. Juodkazis, H. Thissen, R. J. Crawford and E. P. Ivanova, J. Mater. Chem. B, 2019, 7, 4424
    DOI: 10.1039/C9TB00102F

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