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Issue 9, 2019
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Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors

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Abstract

A novel supramolecular multivalent glycosidase inhibitor was constructed based on the amphiphilic deoxynojirimycin derivative FA-DNJ. FA-DNJ self-assembled into spherical assemblies with the diameters between 103 nm and 137 nm under different pH values (pH 2–7) and showed a potent glycosidase effect against α-mannosidase with a Ki value of 0.11 μM, an effect that increased approximately 330-fold compared with that of miglitol. In addition, FA-DNJ exhibited a hypoglycaemic effect in mice.

Graphical abstract: Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors

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Article information


Submitted
11 Dec 2018
Accepted
23 Jan 2019
First published
24 Jan 2019

J. Mater. Chem. B, 2019,7, 1379-1383
Article type
Communication

Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors

M. Li, K. Wang, J. Yang, Y. Peng, Y. Liu, H. Zhang and X. Li, J. Mater. Chem. B, 2019, 7, 1379
DOI: 10.1039/C8TB03249A

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