Jump to main content
Jump to site search

Issue 13, 2019
Previous Article Next Article

Enzymatic crosslinking to fabricate antioxidant peptide-based supramolecular hydrogel for improving cutaneous wound healing

Author affiliations

Abstract

Peptide-based supramolecular hydrogels are promising scaffold materials and have been utilized in many fields. The mechanical properties of peptide hydrogels are usually enhanced by synthetic or natural polymers to expand their application scope. In this study, antioxidant supramolecular hydrogels based on feruloyl-modified peptide and glycol chitosan were fabricated via a mild laccase-mediated crosslinking reaction. A natural polysaccharide derivative, feruloyl glycol chitosan (GC-Fer), was used to enhance the mechanical properties of peptide hydrogels. Feruloyl groups were introduced into the gel matrix via covalent bonds, which endowed the hydrogels with inherent antioxidant properties. This was beneficial for their in vivo application via scavenging harmful free radicals existing in a cutaneous wound. Further in vivo experiments demonstrated that the feruloyl-containing antioxidant hydrogel can improve the cutaneous wound healing process. The regeneration process of mature epithelium and connective tissues was accelerated in a full-thickness skin defect model.

Graphical abstract: Enzymatic crosslinking to fabricate antioxidant peptide-based supramolecular hydrogel for improving cutaneous wound healing

Back to tab navigation

Supplementary files

Article information


Submitted
29 Nov 2018
Accepted
11 Feb 2019
First published
13 Feb 2019

J. Mater. Chem. B, 2019,7, 2220-2225
Article type
Paper

Enzymatic crosslinking to fabricate antioxidant peptide-based supramolecular hydrogel for improving cutaneous wound healing

Q. Wei, J. Duan, G. Ma, W. Zhang, Q. Wang and Z. Hu, J. Mater. Chem. B, 2019, 7, 2220
DOI: 10.1039/C8TB03147A

Social activity

Search articles by author

Spotlight

Advertisements