Polydopamine-coated magnetic mesoporous silica nanoparticles for multimodal cancer theranostics

Menghan Shi; Jiulong Zhang; Jingchao Li; Yu Fan; Jianhong Wang; Wenjie Sun; Hong Yang; Chen Peng; Mingwu Shen; Xiangyang Shi

doi:10.1039/C8TB03021A

Polydopamine-coated magnetic mesoporous silica nanoparticles for multimodal cancer theranostics†

Menghan Shi,^ab Jiulong Zhang,^c Jingchao Li,^b Yu Fan,^b Jianhong Wang,^b Wenjie Sun,^b Hong Yang,*^a Chen Peng,*^c Mingwu Shen

^b and Xiangyang Shi

*^b

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* Corresponding authors

^a The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, People's Republic of China
E-mail: yanghong@shnu.edu.cn

^b College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China
E-mail: xshi@dhu.edu.cn

^c Cancer Center, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, People's Republic of China
E-mail: pengchen_1985@163.com

Abstract

Polydopamine-coated magnetic mesoporous silica nanoparticles have been designed by loading ultrasmall iron oxide nanoparticles within hollow mesoporous silica nanopartricles and then coating polydopamine onto the particle surface. The developed nanoplatform displayed improved colloidal stability, enhanced r₁ relaxivity and near infrared absorption feature, affording their use for multimodal cancer theranostics.

Journal of Materials Chemistry B

Polydopamine-coated magnetic mesoporous silica nanoparticles for multimodal cancer theranostics†

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Polydopamine-coated magnetic mesoporous silica nanoparticles for multimodal cancer theranostics

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