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Issue 11, 2019
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S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE−/− mice

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Abstract

We integrate a biocompatible plant virus-based nanotechnology (tobacco mosaic virus, TMV) with S100A9-targeting peptides for its application in imaging and diagnosis of atherosclerosis. S100A9-targeted TMV nanoparticles exhibit remarkable specificity to S100A9 and targeting of atherosclerosis lesions in ApoE−/− mice.

Graphical abstract: S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE−/− mice

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Article information


Submitted
28 Aug 2018
Accepted
04 Feb 2019
First published
13 Feb 2019

J. Mater. Chem. B, 2019,7, 1842-1846
Article type
Communication

S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE−/− mice

J. Park, H. Gao, Y. Wang, H. Hu, D. I. Simon and N. F. Steinmetz, J. Mater. Chem. B, 2019, 7, 1842
DOI: 10.1039/C8TB02276C

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