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Issue 40, 2018
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Hypoxia-triggered gene therapy: a new drug delivery system to utilize photodynamic-induced hypoxia for synergistic cancer therapy

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Abstract

The therapeutic effects of photodynamic therapy (PDT) are limited by cancer hypoxia because the PDT process is dependent on O2 concentration. Based on this, a new living drug delivery system integrated PDT and hypoxia-triggered gene therapy is proposed, which is made up of three primary constituents: hypoxia-induced cleaved azobenzene (Azo) bridges, HIF-1α-against antisense oligonucleotide (ASO)/G4-constituted double-stranded DNA/RNA hybridization complex (DRHC) and the photosensitizer TMPyP4. During PDT, the continuous consumption of oxygen could remarkably facilitate an intracellular low-oxygen microenvironment. Then, the hypoxia-responsive Azo bridges were reduced by the highly expressed reductases to amines under the oxygen-deficient environment, resulting in a hypoxia-triggered ASO release and providing a synergistic therapy with PDT for suppression of tumor growth. This new drug delivery system opens a new avenue for the design and fabrication of smart drug delivery methods, which can deliver and release drugs according to the specific biological microenvironment in the body.

Graphical abstract: Hypoxia-triggered gene therapy: a new drug delivery system to utilize photodynamic-induced hypoxia for synergistic cancer therapy

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Publication details

The article was received on 11 Jul 2018, accepted on 03 Sep 2018 and first published on 19 Sep 2018


Article type: Paper
DOI: 10.1039/C8TB01805G
Citation: J. Mater. Chem. B, 2018,6, 6424-6430

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    Hypoxia-triggered gene therapy: a new drug delivery system to utilize photodynamic-induced hypoxia for synergistic cancer therapy

    C. Huang, J. Zheng, D. Ma, N. Liu, C. Zhu, J. Li and R. Yang, J. Mater. Chem. B, 2018, 6, 6424
    DOI: 10.1039/C8TB01805G

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