Issue 37, 2018

Direct covalent attachment of silver nanoparticles on radical-rich plasma polymer films for antibacterial applications

Abstract

Prevention and treatment of biomaterial-associated infections (BAI) are imperative requirements for the effective and long-lasting function of orthopedic implants. Surface-functionalization of these materials with antibacterial agents, such as antibiotics, nanoparticles and peptides, is a promising approach to combat BAI. The well-known silver nanoparticles (AgNPs) in particular, although benefiting from strong and broad-range antibacterial efficiency, have been frequently associated with mammalian cell toxicity when physically adsorbed on biomaterials. The majority of irreversible immobilization techniques employed to fabricate AgNP-functionalized surfaces are based on wet-chemistry methods. However, these methods are typically substrate-dependent, complex, and time-consuming. Here we present a simple and dry strategy for the development of polymeric coatings used as platforms for the direct, linker-free covalent attachment of AgNPs onto solid surfaces using ion-assisted plasma polymerization. The resulting coating not only exhibits long-term antibiofilm efficiency against adherent Staphylococcus aureus (S. aureus), but also enhances osteoblast adhesion and proliferation. High resolution X-ray photoelectron spectroscopy (XPS), before and after sodium dodecyl sulfate (SDS) washing, confirms covalent bonding. The development of such silver-functionalized surfaces through a simple, plasma-based process holds great promise for the fabrication of implantable devices with improved tissue-implant integration and reduced biomaterial associated infections.

Graphical abstract: Direct covalent attachment of silver nanoparticles on radical-rich plasma polymer films for antibacterial applications

Article information

Article type
Communication
Submitted
24 May 2018
Accepted
11 Jul 2018
First published
06 Aug 2018

J. Mater. Chem. B, 2018,6, 5845-5853

Direct covalent attachment of silver nanoparticles on radical-rich plasma polymer films for antibacterial applications

B. Akhavan, S. Bakhshandeh, H. Najafi-Ashtiani, A. C. Fluit, E. Boel, C. Vogely, B. C. H. van der Wal, A. A. Zadpoor, H. Weinans, W. E. Hennink, M. M. Bilek and S. Amin Yavari, J. Mater. Chem. B, 2018, 6, 5845 DOI: 10.1039/C8TB01363B

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