Jump to main content
Jump to site search

Issue 41, 2018
Previous Article Next Article

Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing

Author affiliations

Abstract

Here we describe a rapid inkjet formulation method for screening newly-synthesised cationic materials for siRNA delivery into cancer cells. Reduction responsive oligo-β-aminoesters were prepared and evaluated for their ability to condense siRNA into polyplexes through a fast inkjet printing method. A direct relationship between the oligomer structures and charge densities, and the final cell response in terms of uptake rate and transfection efficacy, was found. The oligo-β-aminoesters were well-tolerated by the cancer cells, compared to conventional cationic polymers so far employed in gene delivery, and were as active in silencing of a representative luciferase gene.

Graphical abstract: Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 May 2018, accepted on 01 Jun 2018 and first published on 09 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB01215F
Citation: J. Mater. Chem. B, 2018,6, 6550-6558
  • Open access: Creative Commons BY license
  •   Request permissions

    Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing

    T. Lovato, V. Taresco, A. Alazzo, C. Sansone, S. Stolnik, C. Alexander and C. Conte, J. Mater. Chem. B, 2018, 6, 6550
    DOI: 10.1039/C8TB01215F

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements