Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 41, 2018
Previous Article Next Article

Chitosan/rectorite nanocomposite with injectable functionality for skin hemostasis

Author affiliations

Abstract

Many animals such as snails and Chinese giant salamanders can secrete mucus for moisturizing, eliminating swelling and inflammation, and promoting wound healing; this implies that high viscous bio-functional materials inspired by mucus may show potential for biomedical applications. Herein, we developed a maltose-like injectable nanocomposite via the combination of chitosan polysaccharide and clay rectorite for hemostasis. Through the hemostatic property of rectorite, the viscous nanocomposite decreased the in vitro clotting time by 43%. Moreover, an in vitro porcine skin model confirmed that the viscous nanocomposite can stably adhere on skin and impede blood bleeding successfully. Importantly, the internal structure of the nanocomposites, chitosan intercalating into rectorite interlayers, provided a physical cross-linked network to decrease the release of rectorite from the nanocomposite and its invasion into the blood. Therefore, this viscous injectable nanocomposite provided a concept for a facile and sustainable biomaterial for skin hemostasis.

Graphical abstract: Chitosan/rectorite nanocomposite with injectable functionality for skin hemostasis

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Apr 2018, accepted on 13 Sep 2018 and first published on 19 Sep 2018


Article type: Paper
DOI: 10.1039/C8TB01085D
Citation: J. Mater. Chem. B, 2018,6, 6544-6549

  •   Request permissions

    Chitosan/rectorite nanocomposite with injectable functionality for skin hemostasis

    X. Li, Y. Li, M. Chen, Q. Shi, R. Sun and X. Wang, J. Mater. Chem. B, 2018, 6, 6544
    DOI: 10.1039/C8TB01085D

Search articles by author

Spotlight

Advertisements