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Issue 32, 2018
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Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic

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Abstract

Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.

Graphical abstract: Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic

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Article information


Submitted
25 Apr 2018
Accepted
10 Jul 2018
First published
12 Jul 2018

J. Mater. Chem. B, 2018,6, 5215-5219
Article type
Communication

Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic

S. Yu, K. Luk, S. Cheung, K. W. Kwok, K. Wong and T. Chen, J. Mater. Chem. B, 2018, 6, 5215
DOI: 10.1039/C8TB01084F

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