Jump to main content
Jump to site search

Issue 44, 2018
Previous Article Next Article

Quantum-dot-encapsulated core–shell barcode particles from droplet microfluidics

Author affiliations


The development of robust quantum dot (QD) barcode particles with specific compositions and simple identification is important to meet the demand for high-throughput assays. Here, we present a multiple-inner phase channel capillary microfluidic approach to generate novel QD-encapsulated core–shell barcode particles with distinctive features for multiplexing analysis. By using different QD dispersed polyethylene glycol diacrylate (PEGDA) solutions as the inner phases, the particles were endowed with hydrogel locked QD cores, which could maintain the dispersed status and provide distinctive identification for the particles. The shells of the barcode particles were silica nanoparticle-dispersed ethoxylated trimethylolpropane triacrylate (ETPTA) resin, which could not only improve the stability and biocompatibility of QDs, but also provide functional groups for immobilization of biomolecules due to the assembling of the silica nanoparticles on their surfaces. Due to the advanced emulsification capability of the capillary microfluidic device, double emulsion templates with multiple inner droplet phases and their resultant multicomponent QD-encapsulated core–shell barcode particles could be continually generated. These particles showed remarkable spectral coding capacity in practice, which make them ideal for biomedical applications.

Graphical abstract: Quantum-dot-encapsulated core–shell barcode particles from droplet microfluidics

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Apr 2018, accepted on 19 Jul 2018 and first published on 19 Jul 2018

Article type: Paper
DOI: 10.1039/C8TB00946E
J. Mater. Chem. B, 2018,6, 7257-7262

  •   Request permissions

    Quantum-dot-encapsulated core–shell barcode particles from droplet microfluidics

    F. Bian, H. Wang, L. Sun, Y. Liu and Y. Zhao, J. Mater. Chem. B, 2018, 6, 7257
    DOI: 10.1039/C8TB00946E

Search articles by author