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Issue 28, 2018
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Aggregation-induced emission luminogen-based fluorescence detection of hypoxanthine: a probe for biomedical diagnosis of energy metabolism-related conditions

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Abstract

Hypoxanthine is a well-known indicator of intracellular energy status that is associated with many pathological conditions. We report a fluorescent luminogen (TPE-HPro) with aggregation-induced emission (AIE) feature which, along with xanthine oxidase (XO), detects and quantifies hypoxanthine in a “turn-on” manner. The superior detection performance of this fluorometric assay indicates its great potential for biomedical diagnostics.

Graphical abstract: Aggregation-induced emission luminogen-based fluorescence detection of hypoxanthine: a probe for biomedical diagnosis of energy metabolism-related conditions

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Publication details

The article was received on 24 Mar 2018, accepted on 22 Jun 2018 and first published on 23 Jun 2018


Article type: Communication
DOI: 10.1039/C8TB00803E
Citation: J. Mater. Chem. B, 2018,6, 4575-4578
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    Aggregation-induced emission luminogen-based fluorescence detection of hypoxanthine: a probe for biomedical diagnosis of energy metabolism-related conditions

    Z. Zhang, R. T. K. Kwok, Y. Yu, B. Z. Tang and K. M. Ng, J. Mater. Chem. B, 2018, 6, 4575
    DOI: 10.1039/C8TB00803E

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