Jump to main content
Jump to site search

Issue 19, 2018

Impedance spectroscopic detection of binding and reactions in acid-labile dielectric polymers for biosensor applications

Author affiliations

Abstract

We synthesized previously unreported copolymers with cleavable acid-labile side chains for use as electrochemical sensing layers in order to demonstrate a novel architecture for a one-step immunosensor. This one-step system is in contrast to most antigen-capture signal amplification methods that involve complicated secondary labeling techniques, or require the addition of redox probes to achieve a sensing response. A series of novel copolymers composed of various trityl-containing monomers were synthesized and characterized to determine their dielectric properties. The results indicate that the thin films of these polymers are stable in water, but some begin to degrade under acidic conditions or upon antigen binding, causing observable changes in the phase angle.

Graphical abstract: Impedance spectroscopic detection of binding and reactions in acid-labile dielectric polymers for biosensor applications

Supplementary files

Article information


Submitted
08 Dec 2017
Accepted
19 Apr 2018
First published
19 Apr 2018

J. Mater. Chem. B, 2018,6, 2972-2981
Article type
Communication
Author version available

Impedance spectroscopic detection of binding and reactions in acid-labile dielectric polymers for biosensor applications

J. Dailey, M. Fichera, E. Silbergeld and H. E. Katz, J. Mater. Chem. B, 2018, 6, 2972 DOI: 10.1039/C7TB03171H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements