Nano-functionalized long-period fiber grating probe for disease-specific protein detection

Abstract

Optical biosensors have great significance for rapid and sensitive detection and monitoring of biomolecular interactions. Here, recent advancement in the nano-functionalized long-period fiber grating (LPFG) is used to develop a cost-effective approach for label-free and real-time detection of the carbonic anhydrase-IX (CA9) monoclonal antibody, a diagnostic biomarker in hypoxia condition cultured carcinoma cells.