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Issue 7, 2018

Engineering magnetically responsive tropoelastin spongy-like hydrogels for soft tissue regeneration

Author affiliations

Abstract

Magnetic biomaterials are a key focus in medical research. Tropoelastin is the soluble precursor of elastin and is a critical component of tissues requiring elasticity as part of their physiological function. By utilising the versatility of tropoelastin and the ability to tailor its properties, we developed a novel magnetic spongy-like hydrogel based on tropoelastin doped with magnetic properties by in situ precipitation method. The presence of magnetic nanoparticles altered the secondary structure of tropoelastin. Bioengineered tropoelastin-based magnetic spongy-like hydrogels displayed a homogenous distribution of magnetic nanoparticles throughout the tropoelastin network and quick magnetic responsiveness to an applied external magnetic field. Morphologically, in the presence of magnetic nanoparticles, hydrated tropoelastin spongy-like hydrogels showed apparently smaller pore sizes and less swelling. Furthermore, in vitro biological studies using human tendon-derived cells revealed that magnetically responsive tropoelastin spongy-like hydrogels supported cell viability and enabled cell adhesion, spreading and migration into the interior of the spongy-like hydrogel up to two weeks. The bioengineered tropoelastin-based magnetic spongy-like hydrogel represents a novel class of hybrid biomaterial that can serve as a platform for soft tissue regeneration.

Graphical abstract: Engineering magnetically responsive tropoelastin spongy-like hydrogels for soft tissue regeneration

Supplementary files

Article information


Submitted
30 Jul 2017
Accepted
25 Jan 2018
First published
26 Jan 2018

J. Mater. Chem. B, 2018,6, 1066-1075
Article type
Paper

Engineering magnetically responsive tropoelastin spongy-like hydrogels for soft tissue regeneration

T. Pesqueira, R. Costa-Almeida, S. M. Mithieux, P. S. Babo, A. R. Franco, B. B. Mendes, R. M. A. Domingues, P. Freitas, R. L. Reis, M. E. Gomes and A. S. Weiss, J. Mater. Chem. B, 2018, 6, 1066 DOI: 10.1039/C7TB02035J

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