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Issue 17, 2017
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Dynamic intracellular tracking nanoparticles via pH-evoked “off–on” fluorescence

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Abstract

Dynamic tracking of nanoparticles in cells faces a big challenge due to fluorescence quenching. Here, the pH-switchable probe spiropyran (SP) was introduced into poly(ethylene glycol) (PEG) via atom transfer radical polymerization (ATRP) to construct expected “off–on” fluorescent nanoparticles. Strong red fluorescence was emitted to efficiently track nanoparticles in cells due to the isomerization of spiropyran to merocyanine in the endosome or lysosome.

Graphical abstract: Dynamic intracellular tracking nanoparticles via pH-evoked “off–on” fluorescence

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Article information


Submitted
15 Mar 2017
Accepted
25 Mar 2017
First published
04 Apr 2017

J. Mater. Chem. B, 2017,5, 3107-3110
Article type
Communication

Dynamic intracellular tracking nanoparticles via pH-evoked “off–on” fluorescence

T. Su, F. R. Cheng, J. Cao, J. Q. Yan, X. Y. Peng and B. He, J. Mater. Chem. B, 2017, 5, 3107
DOI: 10.1039/C7TB00713B

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