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Issue 10, 2017
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Design of alveolate Se-inserted TiO2 and its effect on osteosarcoma cells and osteoblasts

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Abstract

Osteosarcoma is a common clinical disease with high incidence, relapse rate and lethality. Thus it is urgently necessary to fabricate bone implants with anti-tumor functions to improve the prognosis of bone cancer. In this study, a novel double-layer TiO2 nano-grid with an outer diameter of 100 nm and an inner diameter of 35 nm is prepared by a simple two-step anodization procedure. In the outer pore of the double-layer TiO2 nano-grid, we precisely embed selenium (Se) nanoparticles using electrodeposition, and this process can be readily tailored by adjusting the time. Biological assays indicate that the prepared Se-embedded TiO2 nano-grid arrays show a dose-dependent anti-tumor effect by inducing apoptosis in MG63 cells. Compared with the Ti substrate, the Se-embedded TiO2 which has a double-layer honeycomb structure facilitates healthy cell (MC3T3-E1) growth when the electrodeposition time is less than 1 h. Thus the novel bone implants have a balanced anti-tumor effect and biocompatibility and are therefore potential candidates for the treatment of osteosarcoma.

Graphical abstract: Design of alveolate Se-inserted TiO2 and its effect on osteosarcoma cells and osteoblasts

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Article information


Submitted
03 Nov 2016
Accepted
26 Jan 2017
First published
27 Jan 2017

J. Mater. Chem. B, 2017,5, 1988-2001
Article type
Paper

Design of alveolate Se-inserted TiO2 and its effect on osteosarcoma cells and osteoblasts

H. Cheng, Z. Gong, H. Hu, M. Zhang, X. Liu, Y. Xu, Y. Zeng, J. Chen and Z. Zhu, J. Mater. Chem. B, 2017, 5, 1988
DOI: 10.1039/C6TB02865A

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